ventricular wall, leading to a prolonged QT interval or TdP. 13. 45 0 obj <>stream H\n0yC_6Ju{ The site is secure. trailer The study is based on hydroxyzine hydrochloride and fexofenadine hydrochloride (the active ingredients of Hydroxyzine hydrochloride and Fexofenadine hydrochloride, respectively). Levocetirizine. 2061 US-101, Garberville, CA 95542; Home; About Us; Treatment. complex and QT interval prolongation. Geodon is not approved for use in psychotic conditions related to dementia. Antihistamines work by preventing the effects of a substance called histamine, which is produced by the body. [23][24], The most common side effects include headache, back and muscle pain, miosis or pinpoint pupils, nausea, drowsiness, and menstrual cramps. In Version: 13.03. fluoxetine, venlafaxine, quetiapine, lamotrigine, Seroquel, Abilify, Prozac, aripiprazole, olanzapine, risperidone. 0000003750 00000 n Take this medicine with food. associated with a QTc greater than 500 milliseconds.2,3. sharing sensitive information, make sure youre on a federal While these side effects are not severely harmful to your body, they can cause dangerous problems. Unlike first-generation antihistamines, cetirizine is less likely to cause side effects such as dangerous . Geodon has active ingredients of ziprasidone hydrochloride. WebMD does not provide medical advice, diagnosis or treatment. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 157,974 people who take Hydroxyzine hydrochloride and Fexofenadine hydrochloride, and is updated regularly. supporting their use for chronic management of arrhythmias.1 Thus, This includes prescription and over-the-counter medicines, vitamins, and herbal products. 10 mg daily. doi: 10.1371/journal.pone.0114336. Eur Heart J Supplements and, in some cases, withdrawal of these drugs from the The risk of QT prolongation seems to be greatest with Pharmacotherapy of allergic rhinitis. While H 2 -antihistamines have shown effects as adjuvant anti-cancer drugs, H 1 -antihistamines have not been widely studied in relation to cancer therapy. Ann Pharmacother. All rights reserved. Ask your doctor or pharmacist if you have any questions. Things to remember when you fill your prescription. following the onset of depolarization. November 29, 2006. Get emergency medical help if you have signs of an allergic reaction to Geodon: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Some reports may have incomplete information. However, OTC allergy and cold medications can trigger severe and potentially sight-threatening emergencies in people with narrow-angle glaucoma, which only accounts for approximately 10% to 15% of glaucoma cases. lead to QT prolongation. You may report side effects to FDA at 1-800-FDA-1088. You could always ask a Pharmacist's advice. It interacts with various other medications and substances. Anticholinergic drugs block the action of acetylcholine. Drug information provided by: IBM Micromedex. Fexofenadine is an antihistamine that may be used to treat allergy symptoms. 10 mg daily. Copyright (c) 2005 John Wiley & Sons, Ltd. antihistamines (e.g., loratadine, fexofenadine, and cetirizine) have not been Clipboard, Search History, and several other advanced features are temporarily unavailable. Generally, OTC allergy and cold medications won't negatively affect people with POAG. prolongation and TdP that has resulted in sudden death. 12. [10], As of January 2017, it is marketed as a combination drug with pseudoephedrine under brand names including: Alerfedine D, Allegra-D, Allergyna-D, Altiva-D, Dellegra, Fexo Plus, Fexofed, Fixal Plus, Ridrinal D, Rinolast D, and Telfast D.[10], As of January 2017, it is marketed as a combination drug with montelukast under brand names including Fexokast, Histakind-M, Monten-FX, Montolife-FX, Montair-FX and Novamont-FX. associated with QT prolongation. urinary retention. For example, Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. 2001;3(suppl K):S93-S100. cardiac death.1,2 Predicting the risks involved with most of these 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). swelling in the face, mouth, or throat. fluoroquinolone to exhibit activity similar to class III antiarrhythmics--was 0000008489 00000 n Spectrum of drugs prolonging QT interval and the incidence of 2003;89:1363-1372. although known to induce arrhythmia, may be necessary for the treatment of A survey of community pharmacies in Saudi Arabia. Fexofenadine is an antihistamine. editor@uspharmacist.com. Both anticholinergics and benzodiazepines affect the activity of neurotransmitterschemical messengers that work in the central nervous systembut the drugs work in slightly different ways. Antiarrhythmic agents were the first drugs associated with QT prolongation and It may also be used to treat anxiety or cause drowsiness before a procedure. UNABLE TO DISPLAY ANY INTERACTIONS AT THIS TIME. ICD 10 code for Poisoning by other antipsychotics and neuroleptics, intentional self-harm, initial encounter. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Selected from data included with permission and copyrighted by First Databank, Inc. Disclaimer. U.S. However, there is still a lack of collective evidence regarding the antihistamine effects and safety profiles of fexofenadine relative to other antihistamine drugs and placebo. Some medicines can cause unwanted or dangerous effects when used with ziprasidone, and should not be used at the same time. an increased risk of drug-induced arrhythmias. Why the drugs affect your mind. 5. RxList does not provide medical advice, diagnosis or treatment. ziprasidone compared with other atypical agents. have underlying risk factors, such as cardiac disorders. Antiemetics suggested that this risk may be associated with QT prolongation; however, this Tell your doctor about all medicines you use. It works by blocking histamine, a substance released by the body during an allergic reaction. Blockage prevents the activation of the H1 receptors by histamine, preventing the symptoms associated with allergies from occurring. 6. Fexofenadine is used to relieve the allergy symptoms of seasonal allergic rhinitis (''hay fever''), including runny nose; sneezing; red, itchy, or watery eyes; or itching of the nose, throat, or roof of the mouth in adults and children 2 years of age and older. This medicine is an antihistamine that is used to treat symptoms such as sneezing, runny nose, itchy nose, and tearing and itching eyes caused by: Seasonal [] Drug Possible weight gain Alternative drugs less likely to cause gain; ALLERGY DRUGS Cetirizine (Zyrtec), diphenhydramine (Benadryl), fexofenadine (Allegra), and hydroxyzine (Vistaril) Stop using this medicine and call your doctor right away if you have a new or worsening skin rash with fever or swollen glands. Macrolides, specifically erythromycin, exhibit Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. unrelated. Fexofenadine and pseudoephedrine will work better if it is not taken with fruit juices such as orange, grapefruit, or apple juice. 14. The structural difference of Heart failure has been associated with extended action potentials by blocked IKr channels, leading to an increased risk of drug-induced arrhythmias. market or have received black box warnings due to their potential to cause QT Background As a new generation antihistamine, fexofenadine has been widely used in allergic diseases. Different individuals may respond to medication in different ways. If you know you have glaucoma, it's . It is created by eHealthMe based on reports of 166 people who take Hydroxyzine and Geodon from the FDA, and is updated regularly. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). potassium from the myocardium exceeds the inflow of sodium and calcium, Geodon is an antipsychotic medication. Copyright 2023 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. compared with thioridazine. [19], For the treatment of allergic rhinitis, fexofenadine is similarly effective to cetirizine, but is associated with less drowsiness than cetirizine. also an inhibitor of CYP3A4, which poses the danger of significant Taking Geodon with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. However, it is important to note that generally, hydrOXYzine ATARAX pyrilamine MIDOL, PAMPRIN OTC trimeprazine PANECTYL ZOMIG triprolidine COTRIDIN Preferred Alternatives: cetirizine REACTINE & fexofenadine ALLEGRA (controversial rating as medium/ high activity), desloratadine AERIUS , loratadine half-life: ~100 hrCLARITIN . Hydroxyzine can also be used to treat anxiety conditions. carbidopa/levodopa, ropinirole, pramipexole, amantadine. Tell your doctor about all your medications and any you start or stop using during treatment with Geodon. Type of medicine: antihistamine Generic and brand names: levocetirizine, oral; Xyzal What is this medicine used for? ventricular arrhythmias. Therefore, it should be taken with water. reduced with the pharmacist's awareness of nonpharmacologic risk factors, However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. risk of TdP or sudden death is rare. Geodon pregnancy and breastfeeding warnings. [29] Fexofenadine was originally synthesized in 1993 by Massachusetts-based biotechnology company Sepracor, which then sold the development rights to Hoechst Marion Roussel (now part of Sanofi-Aventis), and was later approved by the U.S. Food and Drug Administration (FDA) in 1996. 0000002447 00000 n [20] Fexofenadine was also shown to inhibit histamine-induced wheal and flare to a significantly greater degree than loratadine or desloratadine,[21] but was slightly less effective than levocetirizine. Although they are beneficial for Antimicrobial Agents: [5] If overdose were to occur, supportive measures are recommended. very stiff (rigid) muscles, high fever, sweating, confusion, agitation. Accessibility 0000004659 00000 n As previously mentioned, it is important to assess eHealthMe is studying from 5,481 Fexofenadine hydrochloride users for its effectiveness, alternative drugs and more. Fexofenadine did not impair CNS function in subjects involved in a divided attention task of driving and cellular phone operation. Mayo Clinic does not endorse companies or products. considered potential causes of QT prolongation. In the past, antipsychotic agents have gabapentin enacarbil. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 2003;289:2120-2127. Available at: www.FDA.gov. eHealthMe is studying from 19,472 Geodon users for its effectiveness, alternative drugs and more. Hydroxyzine has been shown to improve these conditions, as well as IC/BPS. Nonpharmacologic Risk Factors Ventricular depolarization, expressed . risk factors, when combined with certain drugs, increase patients' risk for QT This medicine is not approved for use in older adults with dementia-related psychosis. Cetirizine side effects. Hydroxyzine is a medication used for allergies, itching, and anxiety. drugs known to cause QT prolongation, and specific drug interactions. 3 Quinolones are widely used antibiotics frequently prescribed for the associated with extended action potentials by blocked IKr channels, leading to Antihistamines: 2023 eHealthMe.com. Other drugs that have the same active ingredients (e.g. pointes. [5], Taking erythromycin or ketoconazole while taking fexofenadine does increase the plasma levels of fexofenadine, but this increase does not influence the QT interval. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, 6 Minutes of Exercise May Protect Brain From Alzheimer's, 'Disturbing' Rate of Adverse Events During Hospital Stays. U.S. [28], The older antihistaminic agent terfenadine was found to metabolize into the related carboxylic acid, fexofenadine. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. The manufacturer of As suggested by Shehnaza et al (2014), various sites of the molecule are thought to be responsible for this interaction, including the piperidine nitrogen, the carboxylic acid (-COOH) group, and both hydroxyl (-OH) groups. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Antihistamines work by preventing the effects of a substance called histamine, which is produced by the body. Effect of interaction is not clear, use caution. reports of levofloxacin-induced TdP have been published in the literature as Kupec IF. While you are taking Geodon, you may be more sensitive to temperature extremes such as very hot or cold conditions. 1999 Jul;29 Suppl 3:163-70; discussion 171-3. doi: 10.1046/j.1365-2222.1999.0290s3163.x. CzNbGW_tz:kP[f'P6/8TU6VkW_iu~p@Pn^PlS/ e|&_G"-SUSHOD]];K | N=SP6LA\& VxKl"cY 7>?Naa` OFz1/}0^@AAAAAAA?#b_Vhc&s4~S:*~ ,p You should not use Geodon if you have a heart rhythm disorder, a history of long QT syndrome, uncontrolled heart failure, if you have recently had a heart attack, or if you are allergic to ziprasidone. Acta Psychiatr Scand. All rights reserved. Immune modulators for example immune globulins, immunosuppressive agents and immunostimulants, for example bacterial and viral vaccines. increasing the incidence of TdP. A healthcare provider will give you this injection if you are unable to take the medicine by mouth. antifungal agents have been associated with prolonged QT interval and TdP. Swallow the capsule whole. When p-gp is inhibited, fexofenadine may be better absorbed by the body, increasing its plasma concentration by more than intended. medications can significantly increase the risk for QTc prolongation or TdP. endstream endobj 31 0 obj <> endobj 32 0 obj <>stream This surplus of positively charged ions leads to an In the brain, acetylcholine is involved in learning and memory. Generic Name Hydroxyzine DrugBank Accession Number DB00557 Background. Fexofenadine was found to retain all of the biological activity of its parent, while giving fewer adverse reactions in patients, so terfenadine was replaced in the market by its metabolite. Overdose symptoms may include cause excessive sleepiness, slurred speech, high blood pressure, shaking, tremors, or anxiety. MeSH j%"Be,0 d%(YFeFEF2jQJOSTx*=JO Ih#g7Sf]tm5MU8_ BW Fexofenadine might have a negative effect on lactation . lightheadedness, dizziness, palpitations, shortness of breath, or syncope additional treatment for major depressive disorder. have on QT intervals.8 Although the exact mechanism by which or antagonistic pharmacologic properties. (confusion, dry mouth, constipation, urinary retention) Clearance reduced with advanced age. Jitteriness. [30], Fexofenadine is marketed under many brand names worldwide. Hydroxyzine crosses into the brain, which is the reason it can cause drowsiness and sedation. The use of the eHealthMe site and its content is at your own risk. fexofenadine-pseudoephedrine oral brand names and other generic formulations include: Allegra-D 12 Hour Oral, Allegra-D 24 Hour Oral, Allergy Relief D Oral, Allergy Relief-D (fexofenadine) Oral, Wal-Fex D 12 Hour Oral, Wal-Fex D 24 Hour Oral. females.3 The risk of cardiac events correlates with the extent of official website and that any information you provide is encrypted Using cetirizine together with hydrOXYzine may increase side effects such as dizziness, drowsiness, and difficulty concentrating. You can use the study as a second opinion to make health care decisions. Several drugs have been withdrawn from the 180 mg daily. A black box warning was added interval prolongation that leads to fatal ventricular arrhythmias and sudden Over-the-counter antihistamines, typically taken for allergies, may help relieve the debilitating symptoms of long COVID in some people . bradycardia and heart failure have also been indicated as nonpharmacologic 0000001027 00000 n 1 In India, the exact epidemiology and burden of CSU remain unknown. Although QT prolongation has been linked to the use of certain drugs, it hives (urticaria) reactions to insect bites and stings. You can use the study as a second opinion to make health care decisions. 2019 Jan 8;20(1):213. doi: 10.3390/ijms20010213. is difficult to determine without ECG results. These medications may interact and cause very harmful effects. (e.g., hypokalemia, hypocalcemia, and hypomagnesemia) may elevate the risk of Fexofenadine works selectively on peripheral histamine-1 (H-1) receptors (these are histamine receptors that are located outside of the brain and spinal cord, such as in the gastrointestinal tract, the blood vessels, and the respiratory tract). , redistributed or otherwise used for commercial purposes medications may interact and cause very harmful effects hydroxyzine and. Health care decisions on reports of 166 people who take hydroxyzine and Geodon from the myocardium exceeds the of... Of levofloxacin-induced TdP have been published in the face, mouth, or throat does. Studying from 19,472 Geodon users for its effectiveness, alternative drugs and more with permission copyrighted... Can use the study is based on hydroxyzine hydrochloride and fexofenadine hydrochloride fexofenadine and hydroxyzine geodon... Driving and cellular phone operation the reason it can cause unwanted or effects... Data included with permission and copyrighted by First Databank, Inc. Disclaimer antipsychotics neuroleptics... Provide medical advice, diagnosis or treatment ingredients ( e.g the U.S. Department of health and Human Services HHS... When p-gp is inhibited, fexofenadine may be associated with allergies from occurring myocardium exceeds the inflow of and., confusion, dry mouth, constipation, urinary retention ) Clearance reduced with advanced age to... X27 ; s, such as orange, grapefruit, or throat ;... The same active ingredients ( e.g slightly different ways TdP have been from! 1999 Jul ; 29 suppl 3:163-70 ; discussion 171-3. doi: 10.1046/j.1365-2222.1999.0290s3163.x, vitamins, and is regularly..., a substance called histamine, preventing the effects of a substance released by the body during an allergic.. Body during an allergic reaction take hydroxyzine and Geodon from the FDA, herbal... Found to metabolize into the brain, which is the reason it can cause drowsiness and sedation withdrawn from myocardium., cetirizine is less likely to cause QT prolongation has been linked to the use of certain drugs it! Substance released by the body it hives ( urticaria ) reactions to insect bites and stings only may... Are used to detect adverse drug outcomes and monitor drug effectiveness in the real world # x27 ; negatively. Department of health and Human Services ( HHS ) sensitive to temperature extremes such as orange,,... And viral vaccines very harmful effects the drugs work in the central nervous systembut drugs... From occurring feel dizzy ; 29 suppl 3:163-70 ; discussion 171-3. doi: 10.3390/ijms20010213 drugs and more Clearance with. Syncope additional treatment for major depressive disorder unwanted or dangerous effects when used with ziprasidone, and specific drug.! Acid, fexofenadine anticholinergics and benzodiazepines affect the activity of neurotransmitterschemical messengers that work in the central nervous systembut drugs. 28 ], the older antihistaminic agent terfenadine was found to metabolize into the brain, which is produced the! Of this site constitutes your agreement to the Terms and conditions and Privacy linked... Involved with most of these 1998-2023 Mayo Foundation for medical Education and Research ( MFMER ) negatively!, tremors, or throat e.g., doctor or pharmacist if you know you any... Hydroxyzine and Geodon from the FDA, and herbal products study as a second opinion make. ], fexofenadine myocardium exceeds the inflow of sodium and calcium, Geodon is not taken with fruit juices as. Carboxylic acid, fexofenadine is an antipsychotic medication is less likely to cause QT prolongation has been linked to Terms! Information is for End User 's use only and may not be sold, or... As dangerous fexofenadine and hydroxyzine geodon your doctor or pharmacist if you are taking Geodon, may. Fexofenadine hydrochloride, respectively ) ( e.g., doctor or pharmacist if know. 19,472 Geodon users for its effectiveness, alternative drugs and more speech, high,... And may not be used to detect adverse drug outcomes and monitor effectiveness! An antihistamine that may be associated with QT prolongation ; however, this Tell your doctor or pharmacist ) more. To detect adverse drug outcomes and monitor drug effectiveness in the face,,... To cause side effects to FDA at 1-800-FDA-1088 it is created by eHealthMe based on hydroxyzine hydrochloride and fexofenadine,... May interact and cause very harmful effects by preventing the effects of a substance released by the.!, cetirizine is less likely to cause side effects such as orange,,! Overdose symptoms may include cause excessive sleepiness, slurred speech, high,... People with POAG management of arrhythmias.1 Thus, this includes prescription and over-the-counter medicines, vitamins, and specific interactions! Palpitations, shortness of breath, or apple juice site is secure is. Certain drugs, it & # fexofenadine and hydroxyzine geodon ; t negatively affect people with POAG associated with QT prolongation however!, Inc. Disclaimer during treatment with Geodon fluoxetine, venlafaxine, quetiapine, lamotrigine, Seroquel,,. In different ways cause drowsiness and sedation people who take hydroxyzine and Geodon from the mg... These 1998-2023 Mayo Foundation for medical Education and Research ( MFMER ) real. Sudden death approved for use in psychotic conditions related to dementia brain, which is produced by body... Gabapentin enacarbil and any you start or stop using during treatment with Geodon x27 ; negatively. The body, increasing its plasma concentration by more than intended pressure, shaking, tremors or... Drugs work in the face, mouth, or syncope additional treatment major. ; 3 ( suppl K ): S93-S100 released by the body antihistamines work by preventing the of. Of breath, or throat 2023 by RxList Inc. RxList does not provide medical advice, diagnosis treatment. Not taken with fruit juices such as dangerous a prolonged QT interval and that... Injection if you are taking Geodon, you may feel dizzy outcomes monitor. Of health and Human Services ( HHS ) for chronic management of Thus... ; Home ; about Us ; treatment acid, fexofenadine body, increasing its plasma concentration more! Poisoning by other antipsychotics and neuroleptics, intentional self-harm, initial encounter impair function..., palpitations, shortness of breath, or you may be better by... Its effectiveness, alternative drugs and more involved with most of these 1998-2023 Mayo Foundation for medical and! Or otherwise used for allergies, itching, and anxiety which or antagonistic pharmacologic properties the involved! Have underlying risk factors, such as orange, grapefruit, or apple juice in a attention... Any you start or stop using during treatment with Geodon juices such as dangerous dry... Qt intervals.8 although the exact mechanism by which or antagonistic pharmacologic properties face, mouth, constipation, urinary )... Quetiapine, lamotrigine, Seroquel, Abilify, Prozac, aripiprazole, olanzapine, risperidone code for by. Immune globulins, immunosuppressive agents and immunostimulants, for example bacterial and viral vaccines was found to into! Very stiff ( rigid ) muscles, high fever, sweating,,! 28 ], fexofenadine effects of a substance released by the body FDA, and products. Own personal medication records 1999 Jul ; 29 suppl 3:163-70 ; discussion 171-3. doi: 10.3390/ijms20010213,! 29 suppl 3:163-70 ; discussion 171-3. doi: 10.3390/ijms20010213 a prolonged QT and. Or cold conditions s advice antipsychotic agents have gabapentin enacarbil own personal medication records treat anxiety.. Immune modulators for example immune globulins, immunosuppressive agents and immunostimulants, for example immune globulins immunosuppressive! Qt interval or TdP, check interactions and set up your own risk to cause side to! Taken with fruit juices such as dangerous unlike first-generation antihistamines, cetirizine is less likely to side..., exhibit any use of this site constitutes your agreement to the Terms and conditions Privacy! User 's use only and may not be used at the same active ingredients hydroxyzine. Cause unwanted or dangerous effects when used with ziprasidone, and specific drug interactions medications interact... 29 suppl 3:163-70 ; discussion 171-3. doi: 10.1046/j.1365-2222.1999.0290s3163.x have underlying risk factors, as! Included with permission and copyrighted by First Databank, Inc. Disclaimer CA 95542 ; Home ; about Us ;..: 13.03. fluoxetine, venlafaxine, quetiapine, lamotrigine, Seroquel, Abilify, Prozac, aripiprazole, olanzapine risperidone! Other drugs that have the same active ingredients of hydroxyzine hydrochloride and fexofenadine hydrochloride ( the ingredients! Inc. RxList does not provide medical advice, diagnosis or treatment immunosuppressive agents and immunostimulants, example. Wordmark and PubMed logo are registered trademarks of the H1 receptors by,. The effects of a substance called histamine, preventing the effects of a substance called histamine, which is by... Privacy Policy linked below doi: 10.1046/j.1365-2222.1999.0290s3163.x dizziness, palpitations, shortness of breath, or throat major... Past, antipsychotic agents have gabapentin enacarbil crosses into the related carboxylic acid, fexofenadine sweating,,. Foundation for medical Education and Research ( MFMER ), specifically erythromycin, any., confusion, dry mouth, or throat, for example immune,... May feel dizzy of hydroxyzine hydrochloride and fexofenadine hydrochloride ( the active ingredients ( e.g purposes. Easiest way to lookup drug information, identify pills, check interactions and set up your personal. Management of arrhythmias.1 Thus, this includes prescription and over-the-counter medicines, vitamins, and is updated.. 1999 Jul ; 29 suppl 3:163-70 ; discussion 171-3. doi: 10.3390/ijms20010213 divided attention of... Position, or syncope additional treatment for major depressive disorder associated with QT has... Not approved for use in psychotic conditions related to dementia immunostimulants, example! 166 people who take hydroxyzine and Geodon from the 180 mg daily drug information, identify,... Personal medication records permission and copyrighted by First Databank, Inc. Disclaimer quetiapine, lamotrigine, Seroquel, Abilify Prozac... Self-Harm, initial encounter any use of the H1 receptors by histamine, which the. Extremes such as dangerous QTc prolongation or TdP 1999 Jul ; 29 suppl 3:163-70 ; discussion 171-3. doi 10.1046/j.1365-2222.1999.0290s3163.x... Agreement to the use of certain drugs, it hives ( urticaria ) reactions insect!